In the first one-day international in Hove, Smriti Mandhana scored a match-winning 91 to lead India to a comfortable seven-wicket victory over England.
India reached their target of 228 with 34 balls remaining thanks to captain Harmanpreet Kaur, who completed 74 unbeaten.
Although England’s young bowlers struggled, Yastika Bhatia also struck 50 for India, and Kate Cross grabbed 2-43.
Before Alice Davidson-Richards’ 50 unbroken runs helped them finish with 227-7, England had fallen to 94-5.
India put up a confident all-around effort and took advantage of their hosts’ inexperience even though they were erratic in the Twenty20 series that England won 2-1.
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While Deepti Sharma claimed 2-33, veteran pitcher Jhulan Goswami only allowed 20 runs and got one wicket in her ten overs.
In the absence of injured captain Heather Knight and Nat Sciver, England’s remaining senior players had to step up. Batter Danni Wyatt contributed a solid 43. But replacement skipper Amy Jones and opener Tammy Beaumont combined for only 10 runs.
In response, India lost Shafali Verma early, but Mandhana and Bhatia added 96 runs for the second wicket after surviving two missed opportunities. Harmanpreet kept her team on pace and ended the game with a six to bring the visitors to 232-3.
On Wednesday, Canterbury will host the second one-day international in the series.