Raducanu ranked 77th in the world, broke Wickmayer’s serve three times in a row to take the opening set.
After being brought to deuce in the previous game, Raducanu broke again to win a cagey second set.
Next, the 19-year-old will face Poland’s Magda Linette, the world’s number 51 player.
Since her remarkable run to the US Open triumph in September 2021, Raducanu’s victory against Linette would be the first time she has won three matches in a single event.
World ranking 460 Before taking a hiatus for the birth of her first child in 2021, Wickmayer was ranked as high as 12th in the world.
After that, however, she grew into the match and was a danger of forcing a decider.
However, Raducanu, who has been training with Dmitry Tursunov since July, maintained her calm and consistency to finish the game in victory.
In other news, Tokyo’s Pan Pacific Open saw reigning winner Naomi Osaka withdraw due to sickness.
In the second round, the 24-year-old was scheduled to take against Brazil’s Beatriz Haddad Maia.
She remarked, “This has always been and always will be a special event for me. I wish I could have played today, but my body won’t allow it.”
Before traveling to her home Japan, the four-time Grand Slam champion, who has dropped to the 48th position in the global rankings, had only won one of her previous seven matches.
Daria Saville, an Australian, tore knee ligaments during their Tuesday match, which resulted in her triumph against Saville in the first round.